exRNAdisease

Entry Detail

---



General Information

Database ID: exR0269729 RNA Name: hsa-miR-34c-5p RNA Type: miRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 111513451 End Site(bp): 111513473 External Links: hsa-miR-34c-5p

Disease Information

Disease Name: Multiple Sclerosis Disease Category: Nervous System Diseases MeSH ID: D009103 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Multiple//Sclerosis, Disseminated//Disseminated Sclerosis//MS (Multiple Sclerosis)//Multiple Sclerosis, Acute Fulminating

Expression Detail

GEO ID: GSE140106 Description: Serum exosome microRNAs predict multiple sclerosis disease activity after fingolimod treatment Experimental Design: Fingolimod treatment Case Disease Type: Multiple Sclerosis Case Disease SubType: NA Case Sample: Fingolimod treated Multiple Sclerosis Control Sample: Untreated Number of Case: 27 Number of Control: 27 Number of Samples: 54

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZDHHC17 chr12 76763588 76853696 + PHF19 chr9 120855651 120894896 - CD151 chr11 832887 839831 + ATXN7L3 chr17 44191805 44200113 - TNRC6B chr22 40044817 40335808 + GATAD2B chr1 153789030 153923360 - SEC61A1 chr3 128051641 128071683 + NFAT5 chr16 69565094 69704666 + NPTX1 chr17 80466834 80477843 - TMEM109 chr11 60914158 60923443 + SUPT6H chr17 28662198 28702679 + ARPP19 chr15 52547045 52569883 - PXDC1 chr6 3722614 3752026 - TRIO chr5 14143342 14532128 + AGTRAP chr1 11736084 11754802 + NCOA1 chr2 24491914 24770702 + JRK chr8 142657460 142681968 - TOB2 chr22 41433494 41446801 - NFKBIA chr14 35401511 35404749 - ANGEL1 chr14 76786168 76826246 - MTMR9 chr8 11284816 11328146 + AMER1 chrX 64185117 64205708 - NECTIN1 chr11 119623408 119729200 - MRPL19 chr2 75646783 75690851 + IGSF3 chr1 116574399 116667755 - FOSL1 chr11 65892049 65900573 - TKFC chr11 61333210 61353295 + CRTC3 chr15 90529923 90645345 + FGFRL1 chr4 1009936 1026898 + ZIC5 chr13 99962964 99971909 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0001865 chr9 86292641 86293514 - hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC018521.1 chr17 47945424 47981736 + AC116913.1 chr15 66488658 66492109 - HCG18 chr6 30286690 30327382 - KCNQ1OT1 chr11 2608328 2699994 - LINC00665 chr19 36313067 36331770 - NEAT1 chr11 65422774 65445540 + SNHG7 chr9 136721366 136728184 - TERC chr3 169764520 169765060 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE140106 Sample Source: Blood Source Fraction: Exosome Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1907 Sample treatment protocol: Exosomes were isolated from 1 mL RNase A (37 °C for 10 min; 100 ng/ml; Qiagen, Australia) treated serum, by size exclusion chromatography (qEV iZONE Science). RNA Extract protocol: Serum exosomes were processed for RNA extraction using the Plasma/Serum Circulating & Exosomal RNA Purification Mini Kit (Norgen Biotek, Cat. 51000) according to the manufacturer's protocol. RNA library preparation protocol: Exosome RNA sequencing libraries were then constructed using the NEBNext Multiplex Small RNA Library Prep Kit for Illumina (BioLabs, New England) according to the manufacturer's instructions.

Reference

PMID: 31721043 Title: Serum Exosome MicroRNAs Predict Multiple Sclerosis Disease Activity after Fingolimod Treatment Author: Ebrahimkhani S, Beadnall HN, Wang C, Suter CM, Barnett MH, Buckland ME, Vafaee F Journal: Mol Neurobiol. 2020 Feb;57(2):1245-1258. Description: we sought the possible utility of serum exosome microRNAs as biomarkers for disease activity in multiple sclerosis patients in response to fingolimod therapy.