exRNAdisease

Entry Detail

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General Information

Database ID: exR0269902 RNA Name: hsa-miR-4508 RNA Type: miRNA Chromosome: chr15 Starnd: - Coordinate: Start Site(bp): 23562107 End Site(bp): 23562123 External Links: hsa-miR-4508

Disease Information

Disease Name: Multiple Sclerosis Disease Category: Nervous System Diseases MeSH ID: D009103 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Multiple//Sclerosis, Disseminated//Disseminated Sclerosis//MS (Multiple Sclerosis)//Multiple Sclerosis, Acute Fulminating

Expression Detail

GEO ID: GSE140106 Description: Serum exosome microRNAs predict multiple sclerosis disease activity after fingolimod treatment Experimental Design: Fingolimod treatment Case Disease Type: Multiple Sclerosis Case Disease SubType: NA Case Sample: Fingolimod treated Multiple Sclerosis Control Sample: Untreated Number of Case: 27 Number of Control: 27 Number of Samples: 54

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand USP22 chr17 20999596 21043760 - AC005943.1 chr19 1578339 1605445 - ADNP2 chr18 80109262 80147523 + ANAPC1 chr2 111611639 111884690 - ANKRD54 chr22 37830855 37849327 - CDC42BPB chr14 102932380 103057549 - COA1 chr7 43608456 43729717 - CSNK1G2 chr19 1941172 1981338 + CTC1 chr17 8224815 8248056 - EID2 chr19 39538707 39540161 - ESYT2 chr7 158730995 158830253 - FUS chr16 31180110 31194871 + LTBP3 chr11 65538805 65558930 - MBD3 chr19 1573596 1592865 - NDUFB4 chr3 120596328 120602507 + OXTR chr3 8750408 8769628 - PROB1 chr5 139390592 139395104 - SCAF4 chr21 31671000 31732118 - SLBP chr4 1692731 1712344 - TM9SF1 chr14 24189149 24195687 - TMCO3 chr13 113491021 113554590 + UBE3A chr15 25333728 25439051 - URI1 chr19 29923644 30016612 + UROS chr10 125784980 125823258 - USP28 chr11 113797874 113875570 - WRAP53 chr17 7686071 7703502 + ZNF580 chr19 55635016 55643470 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand HCG18 chr6 30286690 30327382 - Display:

Experiment Detail

GEO ID: GSE140106 Sample Source: Blood Source Fraction: Exosome Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1907 Sample treatment protocol: Exosomes were isolated from 1 mL RNase A (37 °C for 10 min; 100 ng/ml; Qiagen, Australia) treated serum, by size exclusion chromatography (qEV iZONE Science). RNA Extract protocol: Serum exosomes were processed for RNA extraction using the Plasma/Serum Circulating & Exosomal RNA Purification Mini Kit (Norgen Biotek, Cat. 51000) according to the manufacturer's protocol. RNA library preparation protocol: Exosome RNA sequencing libraries were then constructed using the NEBNext Multiplex Small RNA Library Prep Kit for Illumina (BioLabs, New England) according to the manufacturer's instructions.

Reference

PMID: 31721043 Title: Serum Exosome MicroRNAs Predict Multiple Sclerosis Disease Activity after Fingolimod Treatment Author: Ebrahimkhani S, Beadnall HN, Wang C, Suter CM, Barnett MH, Buckland ME, Vafaee F Journal: Mol Neurobiol. 2020 Feb;57(2):1245-1258. Description: we sought the possible utility of serum exosome microRNAs as biomarkers for disease activity in multiple sclerosis patients in response to fingolimod therapy.