exRNAdisease

Entry Detail

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General Information

Database ID: exR0270163 RNA Name: hsa-miR-532-3p RNA Type: miRNA Chromosome: chrX Starnd: + Coordinate: Start Site(bp): 50003204 End Site(bp): 50003225 External Links: hsa-miR-532-3p

Disease Information

Disease Name: Multiple Sclerosis Disease Category: Nervous System Diseases MeSH ID: D009103 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Multiple//Sclerosis, Disseminated//Disseminated Sclerosis//MS (Multiple Sclerosis)//Multiple Sclerosis, Acute Fulminating

Expression Detail

GEO ID: GSE140106 Description: Serum exosome microRNAs predict multiple sclerosis disease activity after fingolimod treatment Experimental Design: Fingolimod treatment Case Disease Type: Multiple Sclerosis Case Disease SubType: NA Case Sample: Fingolimod treated Multiple Sclerosis Control Sample: Untreated Number of Case: 27 Number of Control: 27 Number of Samples: 54

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABHD2 chr15 89087459 89202355 + ABL2 chr1 179099330 179229684 - CHD2 chr15 92900189 93027996 + FOSL2 chr2 28392448 28417317 + HNRNPH1 chr5 179614178 179634784 - KIAA1522 chr1 32741830 32774970 + NPTN chr15 73560014 73634134 - PACS1 chr11 66070272 66244744 + PHC3 chr3 170086732 170181749 - SIAH2 chr3 150741125 150763477 - SLC7A6 chr16 68264516 68301823 + SMG5 chr1 156249224 156282825 - ZHX3 chr20 41178448 41317672 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL132655.2 chr20 58817132 58817725 - KCNQ1OT1 chr11 2608328 2699994 - LZTS1-AS1 chr8 20275773 20290458 + MALAT1 chr11 65497688 65506516 + MIR34AHG chr1 9148011 9198906 - NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG10 chr14 95521943 95534889 - VPS9D1-AS1 chr16 89711856 89718165 + Display:

Experiment Detail

GEO ID: GSE140106 Sample Source: Blood Source Fraction: Exosome Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1907 Sample treatment protocol: Exosomes were isolated from 1 mL RNase A (37 °C for 10 min; 100 ng/ml; Qiagen, Australia) treated serum, by size exclusion chromatography (qEV iZONE Science). RNA Extract protocol: Serum exosomes were processed for RNA extraction using the Plasma/Serum Circulating & Exosomal RNA Purification Mini Kit (Norgen Biotek, Cat. 51000) according to the manufacturer's protocol. RNA library preparation protocol: Exosome RNA sequencing libraries were then constructed using the NEBNext Multiplex Small RNA Library Prep Kit for Illumina (BioLabs, New England) according to the manufacturer's instructions.

Reference

PMID: 31721043 Title: Serum Exosome MicroRNAs Predict Multiple Sclerosis Disease Activity after Fingolimod Treatment Author: Ebrahimkhani S, Beadnall HN, Wang C, Suter CM, Barnett MH, Buckland ME, Vafaee F Journal: Mol Neurobiol. 2020 Feb;57(2):1245-1258. Description: we sought the possible utility of serum exosome microRNAs as biomarkers for disease activity in multiple sclerosis patients in response to fingolimod therapy.