exRNAdisease

Entry Detail

---



General Information

Database ID: exR0270535 RNA Name: hsa-miR-6884-5p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 40026383 End Site(bp): 40026404 External Links: hsa-miR-6884-5p

Disease Information

Disease Name: Multiple Sclerosis Disease Category: Nervous System Diseases MeSH ID: D009103 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Multiple//Sclerosis, Disseminated//Disseminated Sclerosis//MS (Multiple Sclerosis)//Multiple Sclerosis, Acute Fulminating

Expression Detail

GEO ID: GSE140106 Description: Serum exosome microRNAs predict multiple sclerosis disease activity after fingolimod treatment Experimental Design: Fingolimod treatment Case Disease Type: Multiple Sclerosis Case Disease SubType: NA Case Sample: Fingolimod treated Multiple Sclerosis Control Sample: Untreated Number of Case: 27 Number of Control: 27 Number of Samples: 54

Regulatory Relationship

mRNA targets: NA miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0000552 chr14 71880664 71948928 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005899.4 chr17 32328441 32329395 + AC016065.1 chr8 6403551 6407142 - AC016355.1 chr15 67541072 67542604 - AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC069281.2 chr7 100572232 100578700 - AC074117.1 chr2 27356246 27367622 + AC118758.3 chr7 56809214 56848800 - AL022311.1 chr22 37876148 37895563 + AL132655.2 chr20 58817132 58817725 - AP000662.1 chr11 57638024 57652790 + COL4A2-AS2 chr13 110456396 110463287 - GAS5 chr1 173858559 173868882 - LINC00265 chr7 39733430 39793092 + LINC01278 chrX 63222993 63561095 - LINC01772 chr1 16460948 16468481 + MALAT1 chr11 65497688 65506516 + MIR29B2CHG chr1 207801518 207879115 - NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - SNHG16 chr17 76557764 76565348 + SNHG3 chr1 28505980 28510892 + XIST chrX 73820649 73852723 - ZFHX2-AS1 chr14 23511760 23560778 + Display:

Experiment Detail

GEO ID: GSE140106 Sample Source: Blood Source Fraction: Exosome Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1907 Sample treatment protocol: Exosomes were isolated from 1 mL RNase A (37 °C for 10 min; 100 ng/ml; Qiagen, Australia) treated serum, by size exclusion chromatography (qEV iZONE Science). RNA Extract protocol: Serum exosomes were processed for RNA extraction using the Plasma/Serum Circulating & Exosomal RNA Purification Mini Kit (Norgen Biotek, Cat. 51000) according to the manufacturer's protocol. RNA library preparation protocol: Exosome RNA sequencing libraries were then constructed using the NEBNext Multiplex Small RNA Library Prep Kit for Illumina (BioLabs, New England) according to the manufacturer's instructions.

Reference

PMID: 31721043 Title: Serum Exosome MicroRNAs Predict Multiple Sclerosis Disease Activity after Fingolimod Treatment Author: Ebrahimkhani S, Beadnall HN, Wang C, Suter CM, Barnett MH, Buckland ME, Vafaee F Journal: Mol Neurobiol. 2020 Feb;57(2):1245-1258. Description: we sought the possible utility of serum exosome microRNAs as biomarkers for disease activity in multiple sclerosis patients in response to fingolimod therapy.