exRNAdisease

Entry Detail

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General Information

Database ID: exR0286503 RNA Name: hsa-miR-1294 RNA Type: miRNA Chromosome: chr5 Starnd: + Coordinate: Start Site(bp): 154347153 End Site(bp): 154347174 External Links: hsa-miR-1294

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CYB5R3 chr22 42617840 42649392 - STK40 chr1 36339624 36385896 - EIF4A1 chr17 7572706 7579006 + TRAPPC10 chr21 44012309 44106552 + ABCA1 chr9 104781006 104928155 - POGK chr1 166839447 166856344 + FGFR1 chr8 38400215 38468834 - KMT2A chr11 118436490 118526832 + RAB8A chr19 16111889 16134234 + TEX261 chr2 70985942 70994873 - ANKRD49 chr11 94493979 94499578 + PGRMC1 chrX 119236245 119244466 + PTMS chr12 6765516 6770952 + CRY2 chr11 45847118 45883248 + PTP4A1 chr6 63521746 63583436 + APLP2 chr11 130068147 130144811 + CDKN1B chr12 12715058 12722369 + UBE2G2 chr21 44768580 44801826 - PDPR chr16 70113626 70162537 + AKT2 chr19 40230317 40285536 - RNF157 chr17 76142465 76240493 - ZHX3 chr20 41178448 41317672 - ARHGAP28 chr18 6729718 6915716 + PRRC2B chr9 131373636 131500197 + FYCO1 chr3 45917899 45995824 - ZNF512B chr20 63956704 63969930 - SMAD7 chr18 48919853 48952052 - PDE4DIP chr1 148808181 149048286 + TAGLN2 chr1 159918107 159925732 - NACC1 chr19 13116862 13141147 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000247 chr10 74474868 74475660 + hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0000246 chr10 74468040 74475660 + hsa_circ_0001085 chr2 191765289 191789319 + hsa_circ_0000744 chr17 15968183 15971435 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007161.3 chr7 7640752 8004053 + AC021078.1 chr5 149494314 149504670 - AC022150.4 chr19 52650437 52653284 - AL022311.1 chr22 37876148 37895563 + H19 chr11 1995176 2001470 - LINC00265 chr7 39733430 39793092 + NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.