exRNAdisease

General Information

Database ID:

exR0286546

RNA Name:

hsa-miR-151a-3p

RNA Type:

miRNA

Chromosome:

chr8

Starnd:

Coordinate:

Start Site(bp):

140732587

End Site(bp):

140732607

External Links:

Disease Information

Disease Name:	Drug-induced Liver Injury
Disease Category:	Digestive System Diseases
MeSH ID:	D056486
Type:	Diseases Category/Digestive System Diseases
Alias:	Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID:	GSE59565
Description:	Circulating miRNAs of acetaminophen-overdosed patients
Experimental Design:	Accidental Acetaminophen Overdose
Case Disease Type:	Drug-induced Liver Injury
Case Disease SubType:	NA
Case Sample:	Healthy with APAP Overdose
Control Sample:	Healthy
Number of Case:	18
Number of Control:	6
Number of Samples:	24

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ACP1	chr2	264140	278283	+
PCDHA1	chr5	140786136	141012347	+
PCDHA10	chr5	140855883	141012347	+
PCDHA11	chr5	140868183	141012344	+
PCDHA12	chr5	140875302	141012347	+
PCDHA13	chr5	140882124	141012347	+
PCDHA2	chr5	140794852	141012347	+
PCDHA3	chr5	140801028	141012347	+
PCDHA4	chr5	140806929	141012347	+
PCDHA5	chr5	140821604	141012347	+
PCDHA6	chr5	140827958	141012347	+
PCDHA7	chr5	140834248	141012347	+
PCDHA8	chr5	140841187	141012347	+
PCDHA9	chr5	140847463	141012344	+
PCDHAC1	chr5	140926369	141012344	+
PCDHAC2	chr5	140966470	141012347	+
STRBP	chr9	123109500	123268586	-

miRNA targets:

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC044784.1	chr10	8970125	8973468	+
AC104794.2	chr2	10083781	10086101	+
AL160006.1	chr1	110058340	110062555	+
SCARNA9	chr11	93721513	93721865	+
TUG1	chr22	30969245	30979395	+

Display:

Experiment Detail

GEO ID:	GSE59565
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL11154
Method:	NGS
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2545
Sample treatment protocol:	Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature.
RNA Extract protocol:	Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA)
RNA library preparation protocol:	TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID:	25359176
Title:	Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury
Author:	Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC
Journal:	Toxicol Sci. 2015 Feb;143(2):268-76.
Description:	Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.