exRNAdisease

Entry Detail

General Information

Database ID:

exR0286592

RNA Name:

hsa-miR-197-3p

RNA Type:

miRNA

Chromosome:

chr1

Starnd:

+

Coordinate:

Start Site(bp):

109598940

End Site(bp):

109598961

External Links:

Disease Information

Disease Name:	Drug-induced Liver Injury
Disease Category:	Digestive System Diseases
MeSH ID:	D056486
Type:	Diseases Category/Digestive System Diseases
Alias:	Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID:	GSE59565
Description:	Circulating miRNAs of acetaminophen-overdosed patients
Experimental Design:	Accidental Acetaminophen Overdose
Case Disease Type:	Drug-induced Liver Injury
Case Disease SubType:	NA
Case Sample:	Healthy with APAP Overdose
Control Sample:	Healthy
Number of Case:	18
Number of Control:	6
Number of Samples:	24

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
E2F1	chr20	33675477	33686385	-
REEP4	chr8	22138020	22141951	-

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000591	chr15	41961025	41962156	+
hsa_circ_0001265	chr3	9711115	9712854	+
hsa_circ_0000943	chr19	47421744	47440665	+
hsa_circ_0001387	chr4	1902352	1936989	+
hsa_circ_0000826	chr18	9182379	9221997	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC135050.6	chr16	31122235	31124064	+
MALAT1	chr11	65497688	65506516	+
MIR497HG	chr17	7015818	7019659	-
NEAT1	chr11	65422774	65445540	+
TUG1	chr22	30969245	30979395	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE59565
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL11154
Method:	NGS
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2545
Sample treatment protocol:	Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature.
RNA Extract protocol:	Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA)
RNA library preparation protocol:	TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID:	25359176
Title:	Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury
Author:	Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC
Journal:	Toxicol Sci. 2015 Feb;143(2):268-76.
Description:	Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.