exRNAdisease

General Information

Database ID:

exR0286598

RNA Name:

hsa-miR-199b-5p

RNA Type:

miRNA

Chromosome:

chr9

Starnd:

Coordinate:

Start Site(bp):

128244783

End Site(bp):

128244805

External Links:

Disease Information

Disease Name:	Drug-induced Liver Injury
Disease Category:	Digestive System Diseases
MeSH ID:	D056486
Type:	Diseases Category/Digestive System Diseases
Alias:	Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID:	GSE59565
Description:	Circulating miRNAs of acetaminophen-overdosed patients
Experimental Design:	Accidental Acetaminophen Overdose
Case Disease Type:	Drug-induced Liver Injury
Case Disease SubType:	NA
Case Sample:	Healthy with APAP Overdose
Control Sample:	Healthy
Number of Case:	18
Number of Control:	6
Number of Samples:	24

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ALDH3B2	chr11	67662160	67681224	-
ATP9A	chr20	51596514	51768390	-
CHD2	chr15	92900189	93027996	+
COL4A2	chr13	110305812	110513209	+
COX6A1	chr12	120438090	120440737	+
FAM222B	chr17	28755978	28855232	-
FOSL2	chr2	28392448	28417317	+
HMGCS1	chr5	43287470	43313512	-
KRT80	chr12	52168996	52192014	-
MYRF	chr11	61752642	61788518	+
NFE2L1	chr17	48048329	48061545	+
SLC7A5	chr16	87830023	87869507	-
WNT5A	chr3	55465715	55490539	-
XPO6	chr16	28097979	28211920	-
ZMIZ1	chr10	79068966	79316528	+

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000591	chr15	41961025	41962156	+
hsa_circ_0001005	chr2	53921020	53978078	-
hsa_circ_0000892	chr19	11941431	12014514	+
hsa_circ_0000931	chr19	38226804	38231095	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC004951.4	chr7	43951910	44019151	-
AC095055.1	chr4	151139991	151141103	+
BX284668.2	chr1	16870945	16883659	+
LINC01783	chr1	16533886	16536172	-
POLR2J4	chr7	43940895	44019175	-
SNHG12	chr1	28578538	28583132	-
TMPO-AS1	chr12	98512973	98516422	-

Display:

Experiment Detail

GEO ID:	GSE59565
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL11154
Method:	NGS
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2545
Sample treatment protocol:	Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature.
RNA Extract protocol:	Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA)
RNA library preparation protocol:	TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID:	25359176
Title:	Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury
Author:	Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC
Journal:	Toxicol Sci. 2015 Feb;143(2):268-76.
Description:	Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.