exRNAdisease

Entry Detail

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General Information

Database ID: exR0286635 RNA Name: hsa-miR-23a-3p RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 13836595 End Site(bp): 13836615 External Links: hsa-miR-23a-3p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADGRG6 chr6 142301854 142446266 + ATAD1 chr10 87751512 87841343 - ATXN7L3 chr17 44191805 44200113 - FKBP5 chr6 35573585 35728583 - GATAD2B chr1 153789030 153923360 - IRF4 chr6 391752 411443 + KLF12 chr13 73686089 73995056 - PHLDA1 chr12 76025447 76033932 - TK2 chr16 66508003 66552544 - TNFAIP3 chr6 137867214 137883312 + TOB2 chr22 41433494 41446801 - USP54 chr10 73497538 73625953 - VAT1 chr17 43014607 43025123 - AC008758.1 chr19 12461559 12551474 - ATP5MD chr10 103389041 103396492 - BACE2 chr21 41167801 41282530 + GSTP1 chr11 67583742 67586656 + ZNF709 chr19 12461184 12513854 - ZNF91 chr19 23304991 23395471 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0000711 chr16 68155889 68160513 + hsa_circ_0000881 chr19 5653125 5654467 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007780.1 chr17 68413623 68524949 + AC011503.2 chr19 23927788 23929287 + AC078846.1 chr7 129604548 129611630 - AC091564.7 chr11 6610883 6616594 - AC124068.2 chr15 89335053 89336161 + AC144548.1 chr12 110387463 110445548 - AL035458.2 chr20 34234840 34281173 - GAS5 chr1 173858559 173868882 - MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + SNHG5 chr6 85650491 85678932 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TYMSOS chr18 630886 658340 - XIST chrX 73820649 73852723 - Z93241.1 chr22 42615244 42615907 + ZNF674-AS1 chrX 46545438 46548841 + Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.