exRNAdisease

Entry Detail

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General Information

Database ID: exR0286649 RNA Name: hsa-miR-28-5p RNA Type: miRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 188688794 End Site(bp): 188688815 External Links: hsa-miR-28-5p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RTL8A chrX 135050932 135052196 - LYPD3 chr19 43460787 43465608 - RGMA chr15 93035273 93089204 - GLYR1 chr16 4803203 4847288 - E2F6 chr2 11444375 11466177 - PTPN23 chr3 47381011 47413435 + KCTD5 chr16 2682523 2709030 + GPCPD1 chr20 5544439 5611006 - ENSA chr1 150600851 150629612 - AMOTL2 chr3 134355874 134375479 - SSR2 chr1 156009048 156020951 - FAM102A chr9 127940582 127980989 - N4BP1 chr16 48538726 48620148 - CPSF2 chr14 92121969 92172145 + EZH1 chr17 42700275 42745049 - KIAA1522 chr1 32741830 32774970 + LONRF2 chr2 100271875 100322501 - MAPK1 chr22 21754500 21867680 - LASP1 chr17 38869859 38921770 + SMYD1 chr2 88067825 88113384 + NAPA chr19 47487637 47515091 - URGCP chr7 43875894 43926411 - SMG5 chr1 156249224 156282825 - DYRK1A chr21 37365573 37526358 + RTL8B chrX 135020513 135022542 - SLC31A1 chr9 113221544 113264492 + SEH1L chr18 12947133 12987536 + ZBTB7B chr1 155002630 155018522 + TUB chr11 8019244 8106112 + TEX261 chr2 70985942 70994873 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009065.4 chr16 2119207 2120248 + AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC118758.3 chr7 56809214 56848800 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.