exRNAdisease

Entry Detail

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General Information

Database ID: exR0315630 RNA Name: hsa-miR-1286 RNA Type: miRNA Chromosome: chr22 Starnd: - Coordinate: Start Site(bp): 20249145 End Site(bp): 20249165 External Links: hsa-miR-1286

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TRIO chr5 14143342 14532128 + TXLNA chr1 32179675 32198285 + CSNK1E chr22 38290691 38318084 - NT5DC2 chr3 52524385 52535054 - ERLIN1 chr10 100150094 100186033 - BTG2 chr1 203305491 203309602 + GOLGA3 chr12 132768914 132829078 - ABCA2 chr9 137007234 137028922 - SSR2 chr1 156009048 156020951 - LUZP1 chr1 23084023 23177808 - RUBCN chr3 197668867 197749727 - CBX6 chr22 38861422 38872249 - KMT2A chr11 118436490 118526832 + LAMTOR1 chr11 72085895 72103297 - PHF12 chr17 28905250 28951771 - NPTX1 chr17 80466834 80477843 - ZXDB chrX 57591652 57597545 + PHLDA3 chr1 201464278 201469237 - NIPSNAP1 chr22 29554808 29581327 - IGDCC3 chr15 65327127 65378002 - TNRC6B chr22 40044817 40335808 + DNAJC30 chr7 73680918 73683453 - ALG10B chr12 38316762 38329721 + RBM4 chr11 66638617 66668374 + ABHD14B chr3 51968510 51983409 - ATXN2L chr16 28823035 28837237 + CPA4 chr7 130293134 130324180 + FGFR1 chr8 38400215 38468834 - HDGF chr1 156742109 156766925 - ATP8B2 chr1 154325553 154351304 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001588 chr6 26204839 26205043 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010327.5 chr19 55216660 55221616 + AC016876.2 chr17 7581964 7584086 - AC124068.2 chr15 89335053 89336161 + DNAAF4-CCPG1 chr15 55355248 55498360 - MIR497HG chr17 7015818 7019659 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.