exRNAdisease

Entry Detail

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General Information

Database ID: exR0315638 RNA Name: hsa-miR-129-5p RNA Type: miRNA Chromosome: chr7 Starnd: + Coordinate: Start Site(bp): 128207876 End Site(bp): 128207896 External Links: hsa-miR-129-5p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TNRC6B chr22 40044817 40335808 + KRIT1 chr7 92198969 92246166 - SLC7A2 chr8 17497088 17570573 + TRIM71 chr3 32817997 32897824 + SHCBP1 chr16 46578591 46621379 - NEDD4 chr15 55826922 55993746 - ZNF605 chr12 132918306 132956306 - DDX18 chr2 117814691 117832377 + CPSF7 chr11 61402641 61430031 - RAD1 chr5 34905260 34918989 - UBN2 chr7 139230356 139308236 + DEGS1 chr1 224175756 224193441 + SEC62 chr3 169966635 169998373 + CRK chr17 1420689 1463162 - SLC35E1 chr19 16549831 16572415 - TRIM14 chr9 98069275 98119222 - ALDH5A1 chr6 24494867 24537207 + UFL1 chr6 96521595 96555276 + DUSP14 chr17 37489891 37513501 + WSB1 chr17 27294076 27315926 + DNAJC24 chr11 31369840 31432835 + CHURC1 chr14 64914361 64944591 + MLEC chr12 120687149 120701859 + CAMTA1 chr1 6785454 7769706 + THUMPD1 chr16 20702816 20742084 - EIF4A1 chr17 7572706 7579006 + ACER3 chr11 76860867 77026797 + TTPAL chr20 44475874 44494603 + PDS5A chr4 39822863 39977956 - FBXW7 chr4 152320544 152536092 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004069.1 chr4 105137280 105140619 - AC097634.1 chr3 71584943 71587409 + AL049795.2 chr1 32170733 32176568 + FGD5-AS1 chr3 14920347 14948424 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - OIP5-AS1 chr15 41283990 41309737 + TBC1D3P1-DHX40P1 chr17 59962363 60018975 - TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.