exRNAdisease

Entry Detail

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General Information

Database ID: exR0315722 RNA Name: hsa-miR-149-5p RNA Type: miRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 240456015 End Site(bp): 240456037 External Links: hsa-miR-149-5p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AMOTL2 chr3 134355874 134375479 - CDT1 chr16 88803789 88809258 + FOXP1 chr3 70952817 71583993 - FZD5 chr2 207762598 207769906 - GALNT2 chr1 230057990 230282122 + GNPTAB chr12 101745499 101830959 - ITGA11 chr15 68296532 68432163 - ITGA5 chr12 54395261 54419266 - MAP3K3 chr17 63622415 63696303 + MLLT1 chr19 6210381 6279975 - PHLPP2 chr16 71637835 71724701 - RAB31 chr18 9708275 9862551 + RCC2 chr1 17406760 17439677 - SLC6A6 chr3 14402576 14489349 + SMG5 chr1 156249224 156282825 - WDR36 chr5 111091716 111130502 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0000241 chr10 70847874 70856944 + hsa_circ_0000907 chr19 17212469 17213367 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL035458.2 chr20 34234840 34281173 - AL160006.1 chr1 110058340 110062555 + MALAT1 chr11 65497688 65506516 + MIRLET7BHG chr22 46053869 46113928 + NEAT1 chr11 65422774 65445540 + SNHG8 chr4 118278709 118285316 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.