exRNAdisease

Entry Detail

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General Information

Database ID: exR0315810 RNA Name: hsa-miR-196b-5p RNA Type: miRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 27169528 End Site(bp): 27169549 External Links: hsa-miR-196b-5p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACP1 chr2 264140 278283 + ARHGAP28 chr18 6729718 6915716 + ARL5A chr2 151788984 151828492 - BLOC1S6 chr15 45587214 45615945 + C15orf41 chr15 36579626 36810248 + C19orf53 chr19 13774456 13778773 + COL6A2 chr21 46098112 46132848 + CS chr12 56271699 56300391 - FAM222B chr17 28755978 28855232 - HOXA7 chr7 27153716 27157936 - IGDCC3 chr15 65327127 65378002 - IGF2BP1 chr17 48997385 49056145 + LDOC1 chrX 141111605 141177129 - LYSMD2 chr15 51723011 51751585 - PDE6D chr2 231732433 231786272 - PFKFB3 chr10 6144934 6254644 + TMEM161B chr5 88189633 88269476 - XPO4 chr13 20777329 20903048 - XPO6 chr16 28097979 28211920 - ZMYND11 chr10 134465 254637 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000095 chr1 95609446 95616975 + hsa_circ_0001522 chr5 122881110 122893258 + hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005034.3 chr2 75697583 75697996 + ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - GAS5 chr1 173858559 173868882 - H19 chr11 1995176 2001470 - KCNQ1OT1 chr11 2608328 2699994 - NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.