Entry Detail


General Information

Database ID:exR0315884
RNA Name:hsa-miR-22-3p
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):1713914End Site(bp):1713935
External Links:hsa-miR-22-3p



Disease Information

Disease Name:Benign Breast Disease
Disease Category:Other Diseases
MeSH ID:D001941
Type:Diseases Category/Skin and Connective Tissue Diseases
Alias:Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease



Expression Detail

GEO ID:GSE73002
Description:A circulating microRNA panel to diagnose breast cancer
Experimental Design:Disease vs Control
Case Disease Type:Benign Breast Disease
Case Disease SubType:NA
Case Sample:Benign Breast Disease
Control Sample:Non-Cancer
Number of Case:54
Number of Control:2686
Number of Samples:2740





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CCDC97
chr19
41310172
41324873
+
AP1S1
chr7
101154456
101161596
+
RCOR1
chr14
102592649
102730561
+
RAB11FIP4
chr17
31391675
31538211
+
PPIF
chr10
79347469
79355334
+
FBXL19
chr16
30923055
30948783
+
FNBP4
chr11
47716494
47767443
-
DCP1A
chr3
53283429
53347586
-
GDAP1
chr8
74321130
74488872
+
WSB2
chr12
118032694
118062430
-
ITGA5
chr12
54395261
54419266
-
IRS2
chr13
109752695
109786583
-
FOXP1
chr3
70952817
71583993
-
TMEM179B
chr11
62787402
62790400
+
ETS1
chr11
128458761
128587558
-
ATP2C1
chr3
130850595
131016712
+
ZNF740
chr12
53180704
53195142
+
CACUL1
chr10
118674167
118755249
-
ATP6V0B
chr1
43974487
43978295
+
ACLY
chr17
41866917
41930542
-
CLASP1
chr2
121337776
121649587
-
PRLR
chr5
35048756
35230487
-
PDPR
chr16
70113626
70162537
+
WWC2
chr4
183099257
183320777
+
TAGLN
chr11
117199370
117207464
+
BCL9
chr1
147541501
147626216
+
GLIS2
chr16
4314761
4339597
+
GBF1
chr10
102245532
102382899
+
PDSS1
chr10
26697701
26746798
+
RANBP2
chr2
108719482
108785809
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001699
chr7
40027197
40041630
+
hsa_circ_0001414
chr4
56277780
56284152
+
hsa_circ_0000733
chr17
1561546
1562030
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC021078.1
chr5
149494314
149504670
-
AL360012.1
chr1
28648600
28648730
+
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
SNHG16
chr17
76557764
76565348
+
Display:



Experiment Detail

GEO ID:GSE73002
Sample Source:Blood
Source Fraction:Serum
Platform:GPL18941
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2512
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:26749252
Title:Novel combination of serum microRNA for detecting breast cancer in the early stage
Author:Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T
Journal:Cancer Sci. 2016 Mar;107(3):326-34.
Description:we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.