exRNAdisease

Entry Detail

---



General Information

Database ID: exR0315886 RNA Name: hsa-miR-221-3p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 45746180 End Site(bp): 45746202 External Links: hsa-miR-221-3p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACVR2B chr3 38453890 38493142 + AP3M1 chr10 74120255 74151063 - DNAJC14 chr12 55820960 55830824 - EFNA1 chr1 155127876 155134899 + KDSR chr18 63327726 63367228 - MPZL1 chr1 167721192 167791919 + PPIL1 chr6 36854827 36874803 - TBL1X chrX 9463295 9741037 + TUB chr11 8019244 8106112 + ZBTB5 chr9 37438102 37465450 - DDIT4 chr10 72273924 72276036 + FUS chr16 31180110 31194871 + MAPRE1 chr20 32819954 32850405 + RIPOR2 chr6 24804282 25042170 - SP4 chr7 21428043 21514822 + TUBA1B chr12 49127782 49131397 - ZNF649 chr19 51889235 51905040 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001247 chr22 46125304 46136418 + hsa_circ_0000670 chr16 9199043 9199243 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020978.7 chr16 68224713 68227734 + AC022150.4 chr19 52650437 52653284 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - GAS5 chr1 173858559 173868882 - NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + TYMSOS chr18 630886 658340 - Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.