exRNAdisease

Entry Detail

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General Information

Database ID: exR0316111 RNA Name: hsa-miR-324-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 7223308 End Site(bp): 7223330 External Links: hsa-miR-324-3p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACLY chr17 41866917 41930542 - ATXN7L3 chr17 44191805 44200113 - CDC42EP2 chr11 65314866 65322417 + CELSR2 chr1 109249539 109275751 + DBNDD1 chr16 90004871 90020128 - DCAF15 chr19 13952492 13961449 + FBXL19 chr16 30923055 30948783 + LNPEP chr5 96935394 97037513 + MAPKAPK2 chr1 206684944 206734283 + MXD4 chr4 2247432 2262109 - NACC1 chr19 13116862 13141147 + PDRG1 chr20 31944337 31952046 - SMAD7 chr18 48919853 48952052 - SPTBN2 chr11 66685248 66729226 - SYVN1 chr11 65121780 65134533 - TAGLN chr11 117199370 117207464 + TNFRSF10B chr8 23020133 23069031 - TULP4 chr6 158232236 158511828 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001727 chr7 99621041 99621930 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC040162.3 chr16 67882461 67886367 + AC234582.1 chr1 155195004 155205495 + KCNQ1OT1 chr11 2608328 2699994 - LINC01521 chr22 31346777 31348719 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG22 chr18 49814023 49851059 + Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.