exRNAdisease

Entry Detail

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General Information

Database ID: exR0316130 RNA Name: hsa-miR-339-5p RNA Type: miRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 1022990 End Site(bp): 1023012 External Links: hsa-miR-339-5p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABL2 chr1 179099330 179229684 - ARHGDIA chr17 81867721 81871378 - ATXN7 chr3 63864557 64003462 + EDEM1 chr3 5187646 5219958 + FEM1A chr19 4791734 4801273 + FOXP1 chr3 70952817 71583993 - G3BP2 chr4 75642782 75724525 - MMD chr17 55392622 55421924 - NCOA6 chr20 34689097 34825651 - NUSAP1 chr15 41320794 41381050 + PRDM15 chr21 41798225 41879482 - PTPA chr9 129110950 129148946 + SLC44A1 chr9 105244622 105439171 + STAT3 chr17 42313324 42388568 - VCP chr9 35056064 35072627 - WDR4 chr21 42843094 42879568 - ZNF689 chr16 30602558 30624012 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000120 chr1 117944807 118009049 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004069.1 chr4 105137280 105140619 - AC145207.5 chr17 81878425 81881106 - GAS5 chr1 173858559 173868882 - H19 chr11 1995176 2001470 - KCNQ1OT1 chr11 2608328 2699994 - LINC01578 chr15 92819540 92899701 + NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.