exRNAdisease

Entry Detail

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General Information

Database ID: exR0316155 RNA Name: hsa-miR-361-3p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 85903641 End Site(bp): 85903663 External Links: hsa-miR-361-3p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADD1 chr4 2843857 2930076 + ATP2A3 chr17 3923870 3964464 - C6orf89 chr6 36871870 36928964 + CBX2 chr17 79778148 79787983 + CCDC88C chr14 91271323 91417844 - CDC25B chr20 3786772 3806121 + CTDSP2 chr12 57819927 57846729 - CTSB chr8 11842524 11869448 - EGR1 chr5 138465479 138469303 + FOXP4 chr6 41546426 41602384 + HYOU1 chr11 119044188 119057227 - IGF2BP1 chr17 48997385 49056145 + NACC1 chr19 13116862 13141147 + NPTN chr15 73560014 73634134 - PRMT1 chr19 49675786 49689029 + SH2B1 chr16 28846600 28874212 + SPTBN2 chr11 66685248 66729226 - TNFAIP3 chr6 137867214 137883312 + UBTF chr17 44205033 44221626 - VCL chr10 73995193 74121363 + ZBTB7A chr19 4043303 4066899 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000921 chr19 30476129 30477324 + hsa_circ_0000032 chr1 25666964 25669564 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC092127.1 chr16 85592266 85595720 + KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.