Entry Detail


General Information

Database ID:exR0316189
RNA Name:hsa-miR-3654
RNA Type:miRNA
Chromosome:chr7
Starnd:-
Coordinate:
Start Site(bp):133034860End Site(bp):133034878
External Links:hsa-miR-3654



Disease Information

Disease Name:Benign Breast Disease
Disease Category:Other Diseases
MeSH ID:D001941
Type:Diseases Category/Skin and Connective Tissue Diseases
Alias:Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease



Expression Detail

GEO ID:GSE73002
Description:A circulating microRNA panel to diagnose breast cancer
Experimental Design:Disease vs Control
Case Disease Type:Benign Breast Disease
Case Disease SubType:NA
Case Sample:Benign Breast Disease
Control Sample:Non-Cancer
Number of Case:54
Number of Control:2686
Number of Samples:2740





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TUBB
chr6
30720352
30725426
+
DEPDC1B
chr5
60596912
60700190
-
ERI2
chr16
20780193
20900349
-
CCT7
chr2
73233420
73253021
+
APLP2
chr11
130068147
130144811
+
MRPL11
chr11
66435075
66466738
-
HSPA8
chr11
123057489
123063230
-
GGH
chr8
63015079
63038806
-
MDK
chr11
46380756
46383837
+
EGR1
chr5
138465479
138469303
+
MKRN1
chr7
140453033
140479536
-
RPS14
chr5
150442635
150449739
-
DDTL
chr22
23966888
23972556
+
DCAF8
chr1
160215715
160262549
-
RNPS1
chr16
2253116
2268397
-
DCPS
chr11
126304060
126350005
+
MPRIP
chr17
17042545
17217679
+
RPL12
chr9
127447674
127451406
-
RPL13A
chr19
49487554
49492308
+
RPS12
chr6
132814569
132817564
+
HLA-DRA
chr6
32439878
32445046
+
STMN1
chr1
25884181
25906991
-
RPS3
chr11
75399515
75422280
+
RPL3
chr22
39312882
39320389
-
FTH1
chr11
61959718
61967634
-
TSPAN18
chr11
44726465
44932423
+
HLA-DRB5
chr6
32517353
32530287
-
NOLC1
chr10
102152176
102163871
+
HMGA1
chr6
34236873
34246231
+
CCDC85C
chr14
99500190
99604207
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AD000090.1
chr19
35557956
35581954
+
BCDIN3D-AS1
chr12
49827913
49841143
+
LINC00996
chr7
150433654
150448140
+
Display:



Experiment Detail

GEO ID:GSE73002
Sample Source:Blood
Source Fraction:Serum
Platform:GPL18941
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2512
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:26749252
Title:Novel combination of serum microRNA for detecting breast cancer in the early stage
Author:Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T
Journal:Cancer Sci. 2016 Mar;107(3):326-34.
Description:we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.