exRNAdisease

Entry Detail

---



General Information

Database ID: exR0316425 RNA Name: hsa-miR-431-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 100881026 End Site(bp): 100881046 External Links: hsa-miR-431-5p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ALDH3A2 chr17 19648136 19685760 + ANGEL1 chr14 76786168 76826246 - CA12 chr15 63321378 63381846 - CS chr12 56271699 56300391 - E2F7 chr12 77021248 77065569 - EFNA1 chr1 155127876 155134899 + EI24 chr11 125569280 125584684 + ERG28 chr14 75649791 75660876 - GFPT1 chr2 69319769 69387254 - IGF2BP1 chr17 48997385 49056145 + IRS2 chr13 109752695 109786583 - MBNL1 chr3 152243828 152465780 + PLCB1 chr20 8077251 8968360 + SOX9 chr17 72121020 72126416 + SSH2 chr17 29625938 29930276 - TNFRSF1B chr1 12166991 12209228 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001247 chr22 46125304 46136418 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand ENTPD3-AS1 chr3 40313802 40453329 - Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.