exRNAdisease

Entry Detail

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General Information

Database ID: exR0316708 RNA Name: hsa-miR-4700-3p RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 120723233 End Site(bp): 120723258 External Links: hsa-miR-4700-3p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand GAPDH chr12 6534512 6538374 + PARP1 chr1 226360691 226408093 - SEC61A1 chr3 128051641 128071683 + TTLL12 chr22 43166622 43187134 - UNC119B chr12 120710458 120723640 + CAMTA2 chr17 4967992 4987675 - FBXO2 chr1 11637018 11655785 - HADH chr4 107989714 108035175 + KDM5B chr1 202724495 202808487 - ORMDL1 chr2 189770267 189784364 - PDIA6 chr2 10783391 10837977 - RPL34 chr4 108620566 108630412 + TINAGL1 chr1 31576485 31587686 + TPT1 chr13 45333471 45341370 - WDR1 chr4 10074339 10116949 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.