exRNAdisease

Entry Detail

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General Information

Database ID: exR0316722 RNA Name: hsa-miR-4709-3p RNA Type: miRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 74480135 End Site(bp): 74480157 External Links: hsa-miR-4709-3p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCORL1 chrX 129981107 130058083 + COQ8A chr1 226897536 226987545 + DNAJB6 chr7 157335381 157417439 + LAMC1 chr1 183023420 183145592 + PURA chr5 140107777 140125619 + TMEM167A chr5 83052846 83077863 - BIK chr22 43110750 43129712 + CLSTN3 chr12 7129698 7158945 + DHX16 chr6 30653119 30673006 - EMC4 chr15 34225013 34230156 + ETV3 chr1 157121191 157138474 - GATM chr15 45361124 45402327 - MED1 chr17 39404285 39451272 - MED28 chr4 17614641 17634105 + MSH3 chr5 80654652 80876815 + MTRNR2L12 chr3 96617188 96618236 - NDUFA4 chr7 10931943 10940153 - NPC2 chr14 74476192 74494177 - PLBD1 chr12 14503661 14567883 - PLEKHA5 chr12 19129752 19376400 + RACK1 chr5 181236897 181248096 - RBM15B chr3 51391285 51397908 + SLC50A1 chr1 155135344 155138857 + TPRG1L chr1 3625015 3630127 + WNK1 chr12 752579 911452 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.