exRNAdisease

Entry Detail

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General Information

Database ID: exR0316973 RNA Name: hsa-miR-5100 RNA Type: miRNA Chromosome: chr10 Starnd: + Coordinate: Start Site(bp): 42997630 End Site(bp): 42997651 External Links: hsa-miR-5100

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SNU13 chr22 41673933 41690504 - GHITM chr10 84139509 84153568 + AGRN chr1 1020120 1056118 + PRRC2B chr9 131373636 131500197 + HNRNPH1 chr5 179614178 179634784 - GTF3C4 chr9 132670035 132694953 + PPCDC chr15 75023586 75117462 + SLC35B1 chr17 49700934 49709014 - SRP72 chr4 56467617 56503681 + SRPK1 chr6 35832966 35921342 - CHPF chr2 219538948 219543809 - NOP14 chr4 2937933 2963406 - SLC52A2 chr8 144354135 144361272 + THOP1 chr19 2785503 2815807 + MACF1 chr1 39081316 39487177 + CPTP chr1 1324756 1328896 + UBR4 chr1 19074510 19210266 - ZNF136 chr19 12163064 12189871 + HCN1 chr5 45254948 45696498 - NUP93 chr16 56730118 56850286 + KCTD2 chr17 75032575 75065889 + NIN chr14 50719763 50831121 - KDSR chr18 63327726 63367228 - ATP1A1 chr1 116372668 116410261 + PRMT6 chr1 107056674 107067636 + FLNA chrX 154348524 154374638 - NUP107 chr12 68686951 68745809 + P4HTM chr3 48989889 49007153 + VSIG10 chr12 118063593 118136026 - WASF2 chr1 27404230 27490167 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand POLR2J4 chr7 43940895 44019175 - SNHG3 chr1 28505980 28510892 + AC008738.2 chr19 33305036 33309387 + Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.