exRNAdisease

Entry Detail

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General Information

Database ID: exR0317855 RNA Name: hsa-miR-769-5p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 46018961 End Site(bp): 46018982 External Links: hsa-miR-769-5p

Disease Information

Disease Name: Benign Breast Disease Disease Category: Other Diseases MeSH ID: D001941 Type: Diseases Category/Skin and Connective Tissue Diseases Alias: Breast Diseases//Breast Disease//Disease, Breast//Diseases, Breast//Endocrine Breast Diseases//Breast Disease, Endocrine//Breast Diseases, Endocrine//Disease, Endocrine Breast//Diseases, Endocrine Breast//Endocrine Breast Disease

Expression Detail

GEO ID: GSE73002 Description: A circulating microRNA panel to diagnose breast cancer Experimental Design: Disease vs Control Case Disease Type: Benign Breast Disease Case Disease SubType: NA Case Sample: Benign Breast Disease Control Sample: Non-Cancer Number of Case: 54 Number of Control: 2686 Number of Samples: 2740

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACVR1B chr12 51951699 51997078 + ANGEL1 chr14 76786168 76826246 - ASB1 chr2 238426742 238452250 + BMPR2 chr2 202376327 202567751 + CAPNS1 chr19 36139953 36150353 + CBFB chr16 67028984 67101058 + CLDN11 chr3 170418865 170454733 + CLN8 chr8 1755778 1801711 + DBNDD1 chr16 90004871 90020128 - DCTN4 chr5 150708440 150759109 - EIF1AD chr11 65996545 66002176 - EIF1AX chrX 20124525 20141838 - FOXK1 chr7 4682295 4771442 + LONRF2 chr2 100271875 100322501 - MDM4 chr1 204516379 204558120 + MRTO4 chr1 19251805 19260128 + NUSAP1 chr15 41320794 41381050 + PLCD3 chr17 45108959 45133354 - PRKAA1 chr5 40759379 40798374 - PXN chr12 120210439 120265771 - RHPN1 chr8 143368876 143384221 + RUNX1 chr21 34787801 36004667 - TFAP4 chr16 4257186 4273075 - VAT1 chr17 43014607 43025123 - YPEL5 chr2 30146941 30160533 + ZDHHC9 chrX 129803288 129843909 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC245033.4 chr15 82533175 82540008 - LINC00324 chr17 8220642 8224043 - MALAT1 chr11 65497688 65506516 + SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: GSE73002 Sample Source: Blood Source Fraction: Serum Platform: GPL18941 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 26749252 Title: Novel combination of serum microRNA for detecting breast cancer in the early stage Author: Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T Journal: Cancer Sci. 2016 Mar;107(3):326-34. Description: we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer.