exRNAdisease

Entry Detail

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General Information

Database ID: exR0351949 RNA Name: hsa-miR-105-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 152394458 End Site(bp): 152394480 External Links: hsa-miR-105-5p

Disease Information

Disease Name: Polycystic Ovary Syndrome Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011085 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

Expression Detail

GEO ID: GSE86241 Description: The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome Experimental Design: Disease vs Control Case Disease Type: Polycystic Ovary Syndrome Case Disease SubType: NA Case Sample: Polycystic Ovary Syndrome Control Sample: Control Number of Case: 8 Number of Control: 9 Number of Samples: 17

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARPP19 chr15 52547045 52569883 - DNAJB6 chr7 157335381 157417439 + EXTL2 chr1 100872372 100895179 - GTF2H5 chr6 158168350 158199344 + LMBR1 chr7 156668946 156893216 - MAPKAPK2 chr1 206684944 206734283 + MCL1 chr1 150574551 150579738 - MEF2D chr1 156463727 156500779 - NRIP1 chr21 14961235 15065936 - PDPR chr16 70113626 70162537 + PIK3R3 chr1 46040140 46133036 - PYGB chr20 25248085 25298012 + RAB22A chr20 58309715 58367507 + SLC31A1 chr9 113221544 113264492 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0000987 chr2 30748452 30756180 + hsa_circ_0001414 chr4 56277780 56284152 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC068768.1 chr12 123262060 123262402 + AC079781.5 chr7 97851688 97972985 - AC145207.5 chr17 81878425 81881106 - CYTOR chr2 87454781 87636740 + EPB41L4A-AS1 chr5 112160526 112164818 + FGD5-AS1 chr3 14920347 14948424 - GAS5 chr1 173858559 173868882 - HCG11 chr6 26521709 26527404 + MALAT1 chr11 65497688 65506516 + MCF2L-AS1 chr13 112967484 112968824 - MIR4435-2HG chr2 111006015 111523376 - NNT-AS1 chr5 43571594 43603230 - NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SCAMP1-AS1 chr5 78342365 78360507 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE86241 Sample Source: Blood Source Fraction: Serum Platform: GPL21575 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1951 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted from 200 ul of serum samples using the Exosomal miRNA Purification kit (Genolution, Seoul, Korea). RNA library preparation protocol: Desalted Labeled RNA were prepared from 100ng total RNA Agilent's miRNA Complete Labeling and Hyb Kit.

Reference

PMID: 27677182 Title: The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome Author: Song DK, Sung YA, Lee H Journal: PLoS One. 2016 Sep 27;11(9):e0163756. Description: The present study was performed to examine the role of the serum miRNA as a biomarker for the diagnosis of PCOS and its relationship with metabolic and reproductive traits.