exRNAdisease

Entry Detail

General Information

Database ID:

exR0352131

RNA Name:

hsa-miR-186-5p

RNA Type:

miRNA

Chromosome:

chr1

Starnd:

-

Coordinate:

Start Site(bp):

71067681

End Site(bp):

71067702

External Links:

Disease Information

Disease Name:	Polycystic Ovary Syndrome
Disease Category:	Urogenital Diseases and Pregnancy Complications
MeSH ID:	D011085
Type:	Diseases Category/Female Urogenital Diseases and Pregnancy Complications
Alias:	Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

Expression Detail

GEO ID:	GSE86241
Description:	The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome
Experimental Design:	Disease vs Control
Case Disease Type:	Polycystic Ovary Syndrome
Case Disease SubType:	NA
Case Sample:	Polycystic Ovary Syndrome
Control Sample:	Control
Number of Case:	8
Number of Control:	9
Number of Samples:	17

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
DDX3X	chrX	41333284	41364472	+
EP300	chr22	41092592	41180077	+
GPRC5A	chr12	12890782	12917937	+
NRF1	chr7	129611720	129757082	+
TACSTD2	chr1	58575433	58577252	-
TMEM245	chr9	109015135	109119947	-
TNFRSF21	chr6	47231532	47309905	-
TNKS1BP1	chr11	57299638	57324952	-
HMG20A	chr15	77420412	77485607	+
RNF139	chr8	124474738	124487914	+

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000892	chr19	11941431	12014514	+
hsa_circ_0000799	chr17	65941524	65972074	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC021078.1	chr5	149494314	149504670	-
AC097634.1	chr3	71584943	71587409	+
AC124798.1	chr11	17380649	17383531	+
AC247036.1	chr14	106206603	106208571	+
DLEU2	chr13	49956670	50125720	-
DSCAM-AS1	chr21	40383083	40385358	+
EBLN3P	chr9	37079645	37090928	+
NEAT1	chr11	65422774	65445540	+
OIP5-AS1	chr15	41283990	41309737	+
SNHG3	chr1	28505980	28510892	+
SNHG7	chr9	136721366	136728184	-
TUG1	chr22	30969245	30979395	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE86241
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21575
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	1951
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted from 200 ul of serum samples using the Exosomal miRNA Purification kit (Genolution, Seoul, Korea).
RNA library preparation protocol:	Desalted Labeled RNA were prepared from 100ng total RNA Agilent's miRNA Complete Labeling and Hyb Kit.

Reference

PMID:	27677182
Title:	The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome
Author:	Song DK, Sung YA, Lee H
Journal:	PLoS One. 2016 Sep 27;11(9):e0163756.
Description:	The present study was performed to examine the role of the serum miRNA as a biomarker for the diagnosis of PCOS and its relationship with metabolic and reproductive traits.