exRNAdisease

Entry Detail

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General Information

Database ID: exR0352182 RNA Name: hsa-miR-205-5p RNA Type: miRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 209432166 End Site(bp): 209432187 External Links: hsa-miR-205-5p

Disease Information

Disease Name: Polycystic Ovary Syndrome Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011085 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

Expression Detail

GEO ID: GSE86241 Description: The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome Experimental Design: Disease vs Control Case Disease Type: Polycystic Ovary Syndrome Case Disease SubType: NA Case Sample: Polycystic Ovary Syndrome Control Sample: Control Number of Case: 8 Number of Control: 9 Number of Samples: 17

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DOCK6 chr19 11199295 11262524 - MKRN2 chr3 12557087 12583713 + NUP93 chr16 56730118 56850286 + EP300 chr22 41092592 41180077 + CDC42 chr1 22025511 22101360 + LSM1 chr8 38163335 38176730 - TSPYL4 chr6 116249964 116254075 - HINT1 chr5 131159027 131171735 - YTHDF2 chr1 28736621 28769775 + PPP3CC chr8 22440819 22541142 + SLTM chr15 58879050 58933679 - RUNX1T1 chr8 91954967 92103286 - CALM3 chr19 46601074 46610782 + PRKCSH chr19 11435288 11450968 + SFPQ chr1 35176378 35193145 - PLXNA1 chr3 126988594 127037392 + KAZN chr1 13892792 15118043 + OGDH chr7 44606572 44709066 + ZCCHC8 chr12 122471599 122501073 - SLC25A3 chr12 98593591 98606379 + AFF4 chr5 132875395 132963634 - CAPZA2 chr7 116811070 116922049 + SLC3A2 chr11 62856102 62888875 + ACSL1 chr4 184755595 184826818 - XRCC6 chr22 41621119 41664048 + NDUFAF1 chr15 41387353 41402519 - SOSTDC1 chr7 16461481 16530580 - E2F1 chr20 33675477 33686385 - CCZ1B chr7 6794134 6826770 - GNPDA2 chr4 44682200 44726588 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001434 chr4 106345352 106377902 - hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0000733 chr17 1561546 1562030 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + GAS5 chr1 173858559 173868882 - MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + SNHG5 chr6 85650491 85678932 - AL356133.1 chr9 26801733 26805862 + Display:

Experiment Detail

GEO ID: GSE86241 Sample Source: Blood Source Fraction: Serum Platform: GPL21575 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1951 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted from 200 ul of serum samples using the Exosomal miRNA Purification kit (Genolution, Seoul, Korea). RNA library preparation protocol: Desalted Labeled RNA were prepared from 100ng total RNA Agilent's miRNA Complete Labeling and Hyb Kit.

Reference

PMID: 27677182 Title: The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome Author: Song DK, Sung YA, Lee H Journal: PLoS One. 2016 Sep 27;11(9):e0163756. Description: The present study was performed to examine the role of the serum miRNA as a biomarker for the diagnosis of PCOS and its relationship with metabolic and reproductive traits.