exRNAdisease

Entry Detail

---



General Information

Database ID: exR0352204 RNA Name: hsa-miR-218-5p RNA Type: miRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 168768211 End Site(bp): 168768231 External Links: hsa-miR-218-5p

Disease Information

Disease Name: Polycystic Ovary Syndrome Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011085 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

Expression Detail

GEO ID: GSE86241 Description: The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome Experimental Design: Disease vs Control Case Disease Type: Polycystic Ovary Syndrome Case Disease SubType: NA Case Sample: Polycystic Ovary Syndrome Control Sample: Control Number of Case: 8 Number of Control: 9 Number of Samples: 17

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABI2 chr2 203328239 203447728 + ADCY9 chr16 3953387 4116442 - CPA4 chr7 130293134 130324180 + GRK2 chr11 67266473 67286556 + IGF2 chr11 2129112 2141238 - LCLAT1 chr2 30447226 30644225 + LIN28B chr6 104936616 105083332 + OXSR1 chr3 38165089 38255484 + PARD6B chr20 50731580 50756795 + PRRC1 chr5 127517609 127555089 + RBBP9 chr20 18486540 18497225 - THUMPD1 chr16 20702816 20742084 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0001452 chr4 153562079 153574079 - hsa_circ_0001860 chr9 37126308 37126939 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004069.1 chr4 105137280 105140619 - AC021092.1 chr19 44103007 44113183 - AC125257.1 chr17 41848518 41851447 - ADAMTSL4-AS1 chr1 150560202 150574552 - KCNQ1OT1 chr11 2608328 2699994 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + PSMA3-AS1 chr14 58265365 58298134 - Display:

Experiment Detail

GEO ID: GSE86241 Sample Source: Blood Source Fraction: Serum Platform: GPL21575 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1951 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted from 200 ul of serum samples using the Exosomal miRNA Purification kit (Genolution, Seoul, Korea). RNA library preparation protocol: Desalted Labeled RNA were prepared from 100ng total RNA Agilent's miRNA Complete Labeling and Hyb Kit.

Reference

PMID: 27677182 Title: The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome Author: Song DK, Sung YA, Lee H Journal: PLoS One. 2016 Sep 27;11(9):e0163756. Description: The present study was performed to examine the role of the serum miRNA as a biomarker for the diagnosis of PCOS and its relationship with metabolic and reproductive traits.