exRNAdisease

Entry Detail

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General Information

Database ID: exR0352447 RNA Name: hsa-miR-374b-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 74218587 End Site(bp): 74218608 External Links: hsa-miR-374b-5p

Disease Information

Disease Name: Polycystic Ovary Syndrome Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011085 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

Expression Detail

GEO ID: GSE86241 Description: The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome Experimental Design: Disease vs Control Case Disease Type: Polycystic Ovary Syndrome Case Disease SubType: NA Case Sample: Polycystic Ovary Syndrome Control Sample: Control Number of Case: 8 Number of Control: 9 Number of Samples: 17

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand IPO8 chr12 30628988 30695869 - PLEKHB2 chr2 131104847 131353709 + ATP5F1C chr10 7788147 7807815 + CCT6A chr7 56051685 56063989 + DLGAP5 chr14 55148112 55191608 - DSG2 chr18 31498177 31549008 + FZD6 chr8 103298433 103332866 + GPD1L chr3 32105689 32168713 + GSR chr8 30678066 30727846 - MPP5 chr14 67241342 67336061 + PRKCI chr3 170222424 170305977 + USP1 chr1 62436297 62451804 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010327.5 chr19 55216660 55221616 + AC093010.3 chr3 114314501 114329714 - AL022311.1 chr22 37876148 37895563 + EBLN3P chr9 37079645 37090928 + GAS5 chr1 173858559 173868882 - LINC01184 chr5 127939152 128083172 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE86241 Sample Source: Blood Source Fraction: Serum Platform: GPL21575 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1951 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted from 200 ul of serum samples using the Exosomal miRNA Purification kit (Genolution, Seoul, Korea). RNA library preparation protocol: Desalted Labeled RNA were prepared from 100ng total RNA Agilent's miRNA Complete Labeling and Hyb Kit.

Reference

PMID: 27677182 Title: The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome Author: Song DK, Sung YA, Lee H Journal: PLoS One. 2016 Sep 27;11(9):e0163756. Description: The present study was performed to examine the role of the serum miRNA as a biomarker for the diagnosis of PCOS and its relationship with metabolic and reproductive traits.