exRNAdisease

Entry Detail

General Information

Database ID:

exR0352508

RNA Name:

hsa-miR-425-5p

RNA Type:

miRNA

Chromosome:

chr3

Starnd:

-

Coordinate:

Start Site(bp):

49020199

End Site(bp):

49020221

External Links:

Disease Information

Disease Name:	Polycystic Ovary Syndrome
Disease Category:	Urogenital Diseases and Pregnancy Complications
MeSH ID:	D011085
Type:	Diseases Category/Female Urogenital Diseases and Pregnancy Complications
Alias:	Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

Expression Detail

GEO ID:	GSE86241
Description:	The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome
Experimental Design:	Disease vs Control
Case Disease Type:	Polycystic Ovary Syndrome
Case Disease SubType:	NA
Case Sample:	Polycystic Ovary Syndrome
Control Sample:	Control
Number of Case:	8
Number of Control:	9
Number of Samples:	17

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ABL2	chr1	179099330	179229684	-
FOXC1	chr6	1609915	1613897	+
SH3PXD2A	chr10	103594027	103855543	-
SHC1	chr1	154962298	154974395	-
SLC16A2	chrX	74421493	74533917	+
TRIM22	chr11	5689697	5737089	+

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000591	chr15	41961025	41962156	+
hsa_circ_0000987	chr2	30748452	30756180	+
hsa_circ_0001151	chr20	35236117	35236221	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005034.3	chr2	75697583	75697996	+
AC120036.4	chr8	47190772	47193262	+
KCNQ1OT1	chr11	2608328	2699994	-
LINC01184	chr5	127939152	128083172	-
MALAT1	chr11	65497688	65506516	+
MCM3AP-AS1	chr21	46229196	46259390	+
NEAT1	chr11	65422774	65445540	+
SNHG7	chr9	136721366	136728184	-
SNHG8	chr4	118278709	118285316	+
TUG1	chr22	30969245	30979395	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE86241
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21575
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	1951
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted from 200 ul of serum samples using the Exosomal miRNA Purification kit (Genolution, Seoul, Korea).
RNA library preparation protocol:	Desalted Labeled RNA were prepared from 100ng total RNA Agilent's miRNA Complete Labeling and Hyb Kit.

Reference

PMID:	27677182
Title:	The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome
Author:	Song DK, Sung YA, Lee H
Journal:	PLoS One. 2016 Sep 27;11(9):e0163756.
Description:	The present study was performed to examine the role of the serum miRNA as a biomarker for the diagnosis of PCOS and its relationship with metabolic and reproductive traits.