exRNAdisease

Entry Detail

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General Information

Database ID: exR0353956 RNA Name: hsa-miR-1181 RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 10403505 End Site(bp): 10403525 External Links: hsa-miR-1181

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CDC37 chr19 10391133 10420121 - CHD7 chr8 60678740 60868028 + IRS2 chr13 109752695 109786583 - MAZ chr16 29806106 29811164 + PIM1 chr6 37170152 37175428 + RRP1B chr21 43659560 43696079 + ZMIZ1 chr10 79068966 79316528 + CAMK4 chr5 111223653 111494886 + ELF1 chr13 40931924 41061440 - GNAS chr20 58839718 58911192 + GSPT1 chr16 11868128 11916082 - HNRNPA0 chr5 137745651 137754363 - HNRNPUL2 chr11 62712630 62727457 - HNRNPUL2-BSCL2 chr11 62690275 62727384 - IMMT chr2 86143932 86195770 - MDFIC chr7 114922154 115019202 + PRKAA2 chr1 56645314 56715335 + RAB21 chr12 71754863 71800286 + RALY chr20 33993646 34108308 + SLC4A4 chr4 71062667 71572087 + SOX1 chr13 112067149 112071706 + SPINT2 chr19 38244035 38292615 + TMEFF1 chr9 100473149 100577636 + TTC3 chr21 37073226 37203112 + U2AF1 chr21 43092956 43107587 - U2AF1L5 chr21 6484623 6499261 - UBE2D2 chr5 139526431 139628434 + ZNF282 chr7 149195546 149226238 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007216.1 chr16 11976851 11977850 - Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.