exRNAdisease

Entry Detail

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General Information

Database ID: exR0354073 RNA Name: hsa-miR-1321 RNA Type: miRNA Chromosome: chrX Starnd: + Coordinate: Start Site(bp): 85835832 End Site(bp): 85835849 External Links: hsa-miR-1321

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DDAH1 chr1 85318481 85578363 - WASF2 chr1 27404230 27490167 - KDM5C chrX 53191321 53225422 - C19orf47 chr19 40319536 40348527 - UBE2Q1 chr1 154548577 154559028 - KLC2 chr11 66257294 66267860 + CBFA2T3 chr16 88874858 88977207 - ENSA chr1 150600851 150629612 - ZDHHC9 chrX 129803288 129843909 - MKNK2 chr19 2037465 2051244 - AKIRIN1 chr1 38991276 39006059 + NRF1 chr7 129611720 129757082 + REEP4 chr8 22138020 22141951 - BCL7A chr12 122019422 122062044 + CBX5 chr12 54230942 54280133 - SOX13 chr1 204073115 204127743 + LENG8 chr19 54448887 54462037 + CCND3 chr6 41934933 42050357 - STK35 chr20 2101827 2177038 + GPI chr19 34359480 34402413 + RCOR1 chr14 102592649 102730561 + ONECUT2 chr18 57435374 57491298 + SPTBN2 chr11 66685248 66729226 - WSB2 chr12 118032694 118062430 - ARID1A chr1 26693236 26782104 + HMGA1 chr6 34236873 34246231 + RARA chr17 40309180 40357643 + TP53 chr17 7661779 7687550 - TPP1 chr11 6612768 6619448 - SCD chr10 100347233 100364826 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022167.2 chr16 8848105 8860456 + AC069281.2 chr7 100572232 100578700 - AC124068.2 chr15 89335053 89336161 + AP000233.2 chr21 25095022 25103670 + HCG18 chr6 30286690 30327382 - KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + MIR22HG chr17 1711493 1717174 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + TYMSOS chr18 630886 658340 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.