exRNAdisease

Entry Detail

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General Information

Database ID: exR0354093 RNA Name: hsa-miR-141-3p RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 6964155 End Site(bp): 6964176 External Links: hsa-miR-141-3p

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AK2 chr1 33007940 33080996 - ANP32E chr1 150218417 150236156 - DDX5 chr17 64498254 64508199 - GALNT10 chr5 154190730 154420984 + GFPT1 chr2 69319769 69387254 - HOXC6 chr12 53990624 54030823 + IPO9 chr1 201829149 201884291 + ITPRIPL2 chr16 19113932 19121629 + KRT10 chr17 40818117 40822614 - MYH10 chr17 8474205 8630761 - PDHA1 chrX 19343893 19361718 + PIGW chr17 36534987 36539310 + QKI chr6 163414000 163578592 + QSER1 chr11 32892820 32993316 + RMND5A chr2 86720291 86778041 + UGGT1 chr2 128091200 128195677 + ZNF621 chr3 40524878 40574685 + C6orf62 chr6 24704861 24719998 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001329 chr3 119219541 119222868 + hsa_circ_0001376 chr3 194169185 194175121 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016831.1 chr7 130876809 130913310 - AC023509.1 chr12 53441741 53467528 + AC234582.1 chr1 155195004 155205495 + AL049840.4 chr14 103694516 103695050 - MALAT1 chr11 65497688 65506516 + MIR29B2CHG chr1 207801518 207879115 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + PINK1-AS chr1 20642657 20652193 - SNHG15 chr7 44983023 44986961 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.