exRNAdisease

Entry Detail

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General Information

Database ID: exR0354191 RNA Name: hsa-miR-196a-5p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 48632532 End Site(bp): 48632553 External Links: hsa-miR-196a-5p

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACP1 chr2 264140 278283 + ARHGAP28 chr18 6729718 6915716 + ARL5A chr2 151788984 151828492 - C15orf41 chr15 36579626 36810248 + C19orf53 chr19 13774456 13778773 + CBFA2T3 chr16 88874858 88977207 - COL6A2 chr21 46098112 46132848 + CS chr12 56271699 56300391 - FAM222B chr17 28755978 28855232 - FNBP4 chr11 47716494 47767443 - HOXA7 chr7 27153716 27157936 - IGDCC3 chr15 65327127 65378002 - IGF2BP1 chr17 48997385 49056145 + LDOC1 chrX 141111605 141177129 - PDE6D chr2 231732433 231786272 - PFKFB3 chr10 6144934 6254644 + TMEM161B chr5 88189633 88269476 - XPO4 chr13 20777329 20903048 - ZMYND11 chr10 134465 254637 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000095 chr1 95609446 95616975 + hsa_circ_0001522 chr5 122881110 122893258 + hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005034.3 chr2 75697583 75697996 + ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - GAS5 chr1 173858559 173868882 - H19 chr11 1995176 2001470 - KCNQ1OT1 chr11 2608328 2699994 - NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + SNHG3 chr1 28505980 28510892 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.