exRNAdisease

Entry Detail

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General Information

Database ID: exR0354220 RNA Name: hsa-miR-206 RNA Type: miRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 52144401 End Site(bp): 52144422 External Links: hsa-miR-206

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CAPNS1 chr19 36139953 36150353 + NPEPPS chr17 47522942 47623276 + SPRED1 chr15 38252836 38357249 + SLC30A7 chr1 100896076 100981757 + DDX5 chr17 64498254 64508199 - TRIM2 chr4 153152342 153339317 + DLG3 chrX 70444835 70505490 + LASP1 chr17 38869859 38921770 + RTL8B chrX 135020513 135022542 - FOXP1 chr3 70952817 71583993 - SDCBP chr8 58552924 58582859 + NME1-NME2 chr17 51153590 51171744 + NR2C2 chr3 14947584 15053600 + TNRC6B chr22 40044817 40335808 + CREB3L2 chr7 137874979 138002086 - NETO2 chr16 47077703 47143945 - ZNF518A chr10 96129715 96205288 + PGM2 chr4 37826660 37862937 + PRR12 chr19 49591182 49626439 + PTBP1 chr19 797075 812327 + CALM1 chr14 90396502 90408268 + NME2 chr17 51165435 51171747 + AP1S1 chr7 101154456 101161596 + MAPK1 chr22 21754500 21867680 - GID4 chr17 18039408 18068405 + SMCO4 chr11 93478472 93543391 - SS18 chr18 26016253 26091217 - CWC15 chr11 94962620 94973586 - WIPF2 chr17 40219304 40284136 + WDR5 chr9 134135365 134159968 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000816 chr17 80521229 80526077 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005332.7 chr17 68188547 68189165 + AC145207.5 chr17 81878425 81881106 - LINC00641 chr14 21200079 21206900 - MALAT1 chr11 65497688 65506516 + MIR4435-2HG chr2 111006015 111523376 - NEAT1 chr11 65422774 65445540 + RMRP chr9 35657751 35658018 - Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.