exRNAdisease

Entry Detail

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General Information

Database ID: exR0354268 RNA Name: hsa-miR-23b-3p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 95085265 End Site(bp): 95085287 External Links: hsa-miR-23b-3p

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATAD1 chr10 87751512 87841343 - ATXN7L3 chr17 44191805 44200113 - BRWD1 chr21 39184176 39321559 - CNOT6L chr4 77713387 77819615 - GATAD2B chr1 153789030 153923360 - HMGCS1 chr5 43287470 43313512 - KLF12 chr13 73686089 73995056 - KLF3 chr4 38664197 38701517 + PHLDA1 chr12 76025447 76033932 - TK2 chr16 66508003 66552544 - TNFAIP3 chr6 137867214 137883312 + TOB2 chr22 41433494 41446801 - VDAC1 chr5 133971871 134004975 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0000711 chr16 68155889 68160513 + hsa_circ_0000881 chr19 5653125 5654467 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007780.1 chr17 68413623 68524949 + AC011503.2 chr19 23927788 23929287 + AC078846.1 chr7 129604548 129611630 - AC091564.7 chr11 6610883 6616594 - AC124068.2 chr15 89335053 89336161 + AC144548.1 chr12 110387463 110445548 - AL035458.2 chr20 34234840 34281173 - GAS5 chr1 173858559 173868882 - MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + SNHG5 chr6 85650491 85678932 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TYMSOS chr18 630886 658340 - XIST chrX 73820649 73852723 - Z93241.1 chr22 42615244 42615907 + ZNF674-AS1 chrX 46545438 46548841 + Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.