exRNAdisease

Entry Detail

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General Information

Database ID: exR0354446 RNA Name: hsa-miR-33a-5p RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 41900949 End Site(bp): 41900969 External Links: hsa-miR-33a-5p

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RBM33 chr7 155644451 155781485 + ARCN1 chr11 118572390 118603033 + CROT chr7 87345681 87399795 + PIM1 chr6 37170152 37175428 + BRIP1 chr17 61679139 61863528 - RAB11FIP2 chr10 118004916 118046941 - ECHDC1 chr6 127288712 127343609 - NFAT5 chr16 69565094 69704666 + ZBTB34 chr9 126860665 126885878 + EIF5A2 chr3 170888418 170908644 - XRN1 chr3 142306607 142448062 - WDFY3 chr4 84669610 84966391 - CERK chr22 46684410 46738252 - IGF1R chr15 98648539 98964530 + MYO19 chr17 36495633 36543435 - E2F3 chr6 20401879 20493714 + AFF4 chr5 132875395 132963634 - DDX5 chr17 64498254 64508199 - RCAN1 chr21 34513142 34615113 - GLCCI1 chr7 7968796 8094272 + ROBO1 chr3 78597239 79767998 - RNF11 chr1 51236273 51273447 + AFF3 chr2 99545419 100192428 - ZDHHC9 chrX 129803288 129843909 - ADCY9 chr16 3953387 4116442 - ZFYVE16 chr5 80408013 80483379 + ZNF148 chr3 125225561 125375354 - MAPK1IP1L chr14 55051647 55070194 + CREM chr10 35126791 35212958 + KPNA4 chr3 160495007 160565571 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001349 chr3 152132729 152150709 + hsa_circ_0000642 chr15 80390757 80415142 + hsa_circ_0000643 chr15 80412669 80415142 + hsa_circ_0000284 chr11 33307958 33309057 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + DANCR chr4 52712404 52720351 + FGD5-AS1 chr3 14920347 14948424 - MCF2L-AS1 chr13 112967484 112968824 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.