exRNAdisease

Entry Detail

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General Information

Database ID: exR0354476 RNA Name: hsa-miR-373-3p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53788748 End Site(bp): 53788770 External Links: hsa-miR-373-3p

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand VLDLR chr9 2621787 2660056 + USP24 chr1 55066359 55215364 - CELF2 chr10 10798397 11336675 + APP chr21 25880550 26171128 - KLHL28 chr14 44924319 45042322 - RGMA chr15 93035273 93089204 - PFN2 chr3 149964904 150050788 - FAM177A1 chr14 35044907 35113130 + MBP chr18 76978827 77133683 - CUL1 chr7 148697914 148801110 + MSL1 chr17 40121971 40136917 + RIT1 chr1 155897808 155911404 - ATXN1 chr6 16299112 16761491 - ZFAND4 chr10 45615500 45672780 - SETD7 chr4 139495941 139606699 - BAZ1B chr7 73440406 73522293 - AMPD2 chr1 109616104 109632053 + SLC16A14 chr2 230034982 230068993 - PHC3 chr3 170086732 170181749 - FAM222B chr17 28755978 28855232 - PLEKHM1 chr17 45435900 45490749 - SYAP1 chrX 16719612 16765340 + ARL4A chr7 12686856 12690958 + RACGAP1 chr12 49976923 50033136 - LONP2 chr16 48244300 48363122 + CLIP4 chr2 29097705 29189643 + ADAR chr1 154582057 154628013 - MAGI3 chr1 113390515 113685923 + NAA16 chr13 41311267 41377030 + CLOCK chr4 55427903 55546909 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC125257.1 chr17 41848518 41851447 - AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.