exRNAdisease

Entry Detail

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General Information

Database ID: exR0354662 RNA Name: hsa-miR-512-3p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53666729 End Site(bp): 53666750 External Links: hsa-miR-512-3p

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand IFNAR1 chr21 33324429 33359864 + RAI14 chr5 34656328 34832612 + NAA16 chr13 41311267 41377030 + TOB2 chr22 41433494 41446801 - ASB1 chr2 238426742 238452250 + RIT1 chr1 155897808 155911404 - C9orf40 chr9 74946583 74952912 - STK40 chr1 36339624 36385896 - LETMD1 chr12 51047962 51060424 + IQSEC1 chr3 12897043 13283281 - COQ10B chr2 197453423 197475308 + ZCCHC3 chr20 297570 300321 + FAM120AOS chr9 93431441 93453581 - NSD2 chr4 1871393 1982207 + MTMR12 chr5 32226994 32312987 - ZNF28 chr19 52797408 52857600 - WASL chr7 123681943 123749003 - TOMM6 chr6 41787662 41789898 + AP3M1 chr10 74120255 74151063 - OCRL chrX 129539849 129592561 + SYVN1 chr11 65121780 65134533 - LONP2 chr16 48244300 48363122 + MID1IP1 chrX 38801432 38806537 + SBF1 chr22 50445000 50475035 - TNRC6A chr16 24610209 24827632 + RAB31 chr18 9708275 9862551 + UHRF1BP1 chr6 34792015 34883138 + ERMP1 chr9 5765076 5833117 - ATP6V1E1 chr22 17592136 17628749 - TRIB1 chr8 125430358 125438403 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001159 chr20 40161688 40179999 - hsa_circ_0001865 chr9 86292641 86293514 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC091564.7 chr11 6610883 6616594 - AC092718.4 chr16 81030770 81031485 + FGD5-AS1 chr3 14920347 14948424 - MIR497HG chr17 7015818 7019659 - NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.