exRNAdisease

Entry Detail

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General Information

Database ID: exR0354694 RNA Name: hsa-miR-520d-3p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53720149 End Site(bp): 53720170 External Links: hsa-miR-520d-3p

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CAMK2N1 chr1 20482391 20486210 - KIAA1522 chr1 32741830 32774970 + RGMA chr15 93035273 93089204 - APP chr21 25880550 26171128 - ATP6V1B2 chr8 20197381 20226819 + CUL1 chr7 148697914 148801110 + WASF3 chr13 26557683 26688948 + ATP6V1C1 chr8 103021063 103073051 + FYCO1 chr3 45917899 45995824 - DIP2A chr21 46458891 46570015 + LONP2 chr16 48244300 48363122 + ARL4A chr7 12686856 12690958 + ZSCAN26 chr6 28267010 28278224 + PLAGL2 chr20 32192504 32207743 - MLLT1 chr19 6210381 6279975 - SRRT chr7 100875103 100888664 + AMPD2 chr1 109616104 109632053 + GLCE chr15 69160584 69272217 + ZFAND4 chr10 45615500 45672780 - MTF1 chr1 37809574 37859592 - FAM102A chr9 127940582 127980989 - CCDC93 chr2 117915478 118014133 - VLDLR chr9 2621787 2660056 + ATXN1 chr6 16299112 16761491 - PHC3 chr3 170086732 170181749 - CELF2 chr10 10798397 11336675 + SCAMP2 chr15 74843730 74873365 - SEMA3C chr7 80742538 80922359 - CHD9 chr16 53055033 53329150 + MNT chr17 2384073 2401104 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.