exRNAdisease

Entry Detail

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General Information

Database ID: exR0354718 RNA Name: hsa-miR-545-3p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 74287126 End Site(bp): 74287147 External Links: hsa-miR-545-3p

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANKRD50 chr4 124664048 124712732 - ARRB2 chr17 4710596 4721499 + BVES chr6 105096822 105137157 - CREBRF chr5 173056352 173139284 + FAM89A chr1 231018958 231040254 - NAV1 chr1 201622885 201826969 + SPECC1 chr17 20009344 20319026 + TOB2 chr22 41433494 41446801 - TRIM33 chr1 114392790 114511203 - UTRN chr6 144285701 144853034 + WDR4 chr21 42843094 42879568 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001409 chr4 48835417 48859382 + hsa_circ_0000458 chr12 124071293 124074996 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001452 chr4 153562079 153574079 - hsa_circ_0001263 chr3 5215701 5216099 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC114980.1 chr5 93860669 93863825 - AC125257.1 chr17 41848518 41851447 - AC245033.4 chr15 82533175 82540008 - GAS5 chr1 173858559 173868882 - LINC00476 chr9 95759231 95876049 - MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + RRN3P2 chr16 29074976 29116718 + SNHG1 chr11 62851984 62855953 - TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.