exRNAdisease

Entry Detail

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General Information

Database ID: exR0354852 RNA Name: hsa-miR-650 RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 22822791 End Site(bp): 22822811 External Links: hsa-miR-650

Disease Information

Disease Name: Glioblastoma Multiforme Disease Category: Cancers MeSH ID: D005909 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Glioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

Expression Detail

GEO ID: GSE93850 Description: Serum miRNAs in Patients with Glioblastoma Multiforme Experimental Design: Cancer vs Control Case Disease Type: Glioblastoma Multiforme Case Disease SubType: NA Case Sample: Glioblastoma Multiforme Control Sample: Healthy Number of Case: 22 Number of Control: 8 Number of Samples: 30

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand POM121C chr7 75416786 75486299 - ATXN2L chr16 28823035 28837237 + RNF220 chr1 44405194 44651724 + POLE3 chr9 113407235 113410675 - SFN chr1 26863149 26864456 + SH3GL1 chr19 4360370 4400547 - STOM chr9 121338987 121370304 - HNRNPUL1 chr19 41262496 41307787 + LMNA chr1 156082573 156140089 + SLC9A3R1 chr17 74748628 74769353 + HPCAL1 chr2 10302889 10427617 + TRAF7 chr16 2155698 2178129 + GBF1 chr10 102245532 102382899 + ZNF623 chr8 143636013 143656418 + USP22 chr17 20999596 21043760 - POLDIP3 chr22 42583721 42614962 - VHL chr3 10141008 10152220 + ABL1 chr9 130713016 130887675 + TSKU chr11 76782251 76798153 + TRAPPC10 chr21 44012309 44106552 + SLC29A1 chr6 44219553 44234142 + HIF1AN chr10 100529072 100559998 + NBL1 chr1 19596979 19658456 + AFAP1 chr4 7758714 7939926 - CBFA2T3 chr16 88874858 88977207 - AKT2 chr19 40230317 40285536 - RAB1B chr11 66268590 66277492 + PAK4 chr19 39125770 39182816 + DUSP8 chr11 1554051 1572271 - TESMIN chr11 68707440 68751520 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC068768.1 chr12 123262060 123262402 + AC118758.3 chr7 56809214 56848800 - AL049796.1 chr1 93847174 93848939 + AL355075.4 chr14 20343048 20343685 - DSCAM-AS1 chr21 40383083 40385358 + KCNQ1OT1 chr11 2608328 2699994 - LINC01772 chr1 16460948 16468481 + MIR155HG chr21 25561909 25575168 + MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE93850 Sample Source: Blood Source Fraction: Serum Platform: GPL22948 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1032 Sample treatment protocol: NA RNA Extract protocol: Serum total RNA was isolated from serum samples using the Plasma/Serum Circulating and Exosomal RNA Purification Mini Kit (Slurry Format) (Norgen Biotek Corporation, Thorold, Ontario, Canada) RNA library preparation protocol: 0.3ug of total RNA of intrahepatic cholangiocarcinoma/normal intrahepatic bile duct tissue was employed with 100 nmol/L of pCp-DY547 (Dharmacon, Lafayette, CO, USA) and 15 Units of T4 RNA ligase (USB, Cleveland, Oh, USA) in a total reaction volume of 20 ul at 16°C overnight.

Reference

PMID: 28931080 Title: Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma Author: Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY,Wu SX Journal: PLoS One. 2017 Sep 20;12(9):e0184969. Description: we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM.