exRNAdisease

Entry Detail

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General Information

Database ID: exR0356203 RNA Name: hsa-miR-105-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 152394458 End Site(bp): 152394480 External Links: hsa-miR-105-5p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARPP19 chr15 52547045 52569883 - DNAJB6 chr7 157335381 157417439 + EXTL2 chr1 100872372 100895179 - GTF2H5 chr6 158168350 158199344 + LMBR1 chr7 156668946 156893216 - MAPKAPK2 chr1 206684944 206734283 + MCL1 chr1 150574551 150579738 - MEF2D chr1 156463727 156500779 - NRIP1 chr21 14961235 15065936 - PDPR chr16 70113626 70162537 + PIK3R3 chr1 46040140 46133036 - PYGB chr20 25248085 25298012 + RAB22A chr20 58309715 58367507 + SLC31A1 chr9 113221544 113264492 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0000987 chr2 30748452 30756180 + hsa_circ_0001414 chr4 56277780 56284152 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC068768.1 chr12 123262060 123262402 + AC079781.5 chr7 97851688 97972985 - AC145207.5 chr17 81878425 81881106 - CYTOR chr2 87454781 87636740 + EPB41L4A-AS1 chr5 112160526 112164818 + FGD5-AS1 chr3 14920347 14948424 - GAS5 chr1 173858559 173868882 - HCG11 chr6 26521709 26527404 + MALAT1 chr11 65497688 65506516 + MCF2L-AS1 chr13 112967484 112968824 - MIR4435-2HG chr2 111006015 111523376 - NNT-AS1 chr5 43571594 43603230 - NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SCAMP1-AS1 chr5 78342365 78360507 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.