exRNAdisease

General Information

Database ID:

exR0356218

RNA Name:

hsa-miR-1181

RNA Type:

miRNA

Chromosome:

chr19

Starnd:

Coordinate:

Start Site(bp):

10403505

End Site(bp):

10403525

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
CDC37	chr19	10391133	10420121	-
CHD7	chr8	60678740	60868028	+
IRS2	chr13	109752695	109786583	-
MAZ	chr16	29806106	29811164	+
PIM1	chr6	37170152	37175428	+
RRP1B	chr21	43659560	43696079	+
ZMIZ1	chr10	79068966	79316528	+
CAMK4	chr5	111223653	111494886	+
ELF1	chr13	40931924	41061440	-
GNAS	chr20	58839718	58911192	+
GSPT1	chr16	11868128	11916082	-
HNRNPA0	chr5	137745651	137754363	-
HNRNPUL2	chr11	62712630	62727457	-
HNRNPUL2-BSCL2	chr11	62690275	62727384	-
IMMT	chr2	86143932	86195770	-
MDFIC	chr7	114922154	115019202	+
PRKAA2	chr1	56645314	56715335	+
RAB21	chr12	71754863	71800286	+
RALY	chr20	33993646	34108308	+
SLC4A4	chr4	71062667	71572087	+
SOX1	chr13	112067149	112071706	+
SPINT2	chr19	38244035	38292615	+
TMEFF1	chr9	100473149	100577636	+
TTC3	chr21	37073226	37203112	+
U2AF1	chr21	43092956	43107587	-
U2AF1L5	chr21	6484623	6499261	-
UBE2D2	chr5	139526431	139628434	+
ZNF282	chr7	149195546	149226238	+

miRNA targets:

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007216.1	chr16	11976851	11977850	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.