Entry Detail



General Information

Database ID:exR0356239
RNA Name:hsa-miR-122-5p
RNA Type:miRNA
Chromosome:chr18
Starnd:+
Coordinate:
Start Site(bp):58451088End Site(bp):58451109
External Links:hsa-miR-122-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MSI2
chr17
57255851
57684689
+
FAM102A
chr9
127940582
127980989
-
NAGK
chr2
71064344
71079808
+
SPRED2
chr2
65310851
65432637
-
HGSNAT
chr8
43140464
43202855
+
PPDPF
chr20
63520765
63522206
+
SH3GL1
chr19
4360370
4400547
-
SETD1A
chr16
30957754
30984664
+
PEA15
chr1
160205337
160215376
+
C19orf54
chr19
40740856
40751553
-
PIP4K2A
chr10
22534854
22714578
-
RPRD1B
chr20
38033725
38127780
+
CACNG4
chr17
66964707
67033398
+
SOX11
chr2
5692384
5701385
+
IGFBP5
chr2
216672105
216695549
-
RAB1B
chr11
66268590
66277492
+
CSRP1
chr1
201483530
201509456
-
VTI1A
chr10
112446998
112818744
+
ZNF3
chr7
100064033
100082548
-
NHLRC3
chr13
39038306
39050109
+
ZNF614
chr19
52012765
52030240
-
NDOR1
chr9
137205685
137217009
+
ALDOA
chr16
30064164
30070457
+
GRK3
chr22
25564675
25729294
+
C19orf47
chr19
40319536
40348527
-
SLC9A1
chr1
27098809
27166981
-
STK4
chr20
44966479
45080021
+
IER2
chr19
13150411
13154911
+
PRR12
chr19
49591182
49626439
+
KRT7
chr12
52232520
52252186
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC021092.1
chr19
44103007
44113183
-
AC103702.1
chr17
48579630
48582259
-
AL358472.3
chr1
153966516
153966930
+
AL645465.1
chr1
244375100
244409592
-
DSCAM-AS1
chr21
40383083
40385358
+
NEAT1
chr11
65422774
65445540
+
SNHG7
chr9
136721366
136728184
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.