Entry Detail



General Information

Database ID:exR0356264
RNA Name:hsa-miR-124-3p
RNA Type:miRNA
Chromosome:chr8
Starnd:+
Coordinate:
Start Site(bp):64379210End Site(bp):64379231
External Links:hsa-miR-124-3p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CDH1
chr16
68737292
68835541
+
MDK
chr11
46380756
46383837
+
TRAPPC10
chr21
44012309
44106552
+
COL12A1
chr6
75084326
75206053
-
RANBP10
chr16
67723070
67806652
-
TSEN54
chr17
75516060
75524735
+
ZCCHC24
chr10
79382325
79445624
-
ASF1B
chr19
14119512
14136613
-
RPS10-NUDT3
chr6
34284887
34426071
-
JAG1
chr20
10637684
10673999
-
RPS6KA3
chrX
20149911
20267519
-
CTDSP1
chr2
218398256
218405941
+
NUDT3
chr6
34279679
34392669
-
FAM102A
chr9
127940582
127980989
-
MMS22L
chr6
97142161
97283217
-
EPHB4
chr7
100802565
100827523
-
ANGPTL2
chr9
127087348
127122635
-
BLOC1S5-TXNDC5
chr6
7881522
8064364
-
PAPSS2
chr10
87659613
87747705
+
C20orf27
chr20
3753508
3768387
-
MOB4
chr2
197515571
197553699
+
SCAMP2
chr15
74843730
74873365
-
CDKN2A
chr9
21967753
21995301
-
G3BP2
chr4
75642782
75724525
-
ZSCAN22
chr19
58326994
58342332
+
ANKRD52
chr12
56237807
56258384
-
NFAT5
chr16
69565094
69704666
+
CREB3L2
chr7
137874979
138002086
-
CLASP1
chr2
121337776
121649587
-
MLLT1
chr19
6210381
6279975
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001186
chr21
35475133
35475818
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC008040.1
chr3
169939353
169966734
-
AC069281.2
chr7
100572232
100578700
-
AC084082.1
chr8
66112667
66126632
+
FGD5-AS1
chr3
14920347
14948424
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC00240
chr6
26956932
27059749
+
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
SNHG16
chr17
76557764
76565348
+
TMEM147-AS1
chr19
35540738
35546029
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.