exRNAdisease

General Information

Database ID:

exR0356267

RNA Name:

hsa-miR-1244

RNA Type:

miRNA

Chromosome:

chr2

Starnd:

Coordinate:

Start Site(bp):

231713368

End Site(bp):

231713393

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
RHOA	chr3	49359145	49412998	-
CPNE3	chr8	86514435	86561498	+
KIAA1191	chr5	176346062	176361807	-
ZMYM4	chr1	35268709	35422058	+
CCT2	chr12	69585426	69601570	+
AL590764.2	chrX	71103987	71111575	-
RPS5	chr19	58386400	58394806	+
UBA2	chr19	34428352	34471251	+
CDC42EP3	chr2	37641882	37738468	-
EEF1G	chr11	62559596	62574086	-
GAK	chr4	849276	932373	-
SPIN1	chr9	88388430	88478694	+
ERLIN1	chr10	100150094	100186033	-
MT-CO3	chrMT	9207	9990	+
HNRNPU	chr1	244840638	244864560	-
TOLLIP	chr11	1274371	1309654	-
MLF2	chr12	6747996	6767475	-
CCDC18	chr1	93179919	93278730	+
MBD3	chr19	1573596	1592865	-
RPS2	chr16	1962058	1964841	-
PTMA	chr2	231706895	231713541	+
UBC	chr12	124911604	124917368	-
OAS2	chr12	112978395	113011723	+
APELA	chr4	164877178	164898965	+
SLC7A1	chr13	29509414	29595688	-
ARHGDIB	chr12	14942031	14961728	-
ARMT1	chr6	151452258	151470101	+
AP002990.1	chr11	62559603	62591531	-
B2M	chr15	44711487	44718877	+
RFWD3	chr16	74621399	74666877	-

miRNA targets:

circRNA targets:

lncRNA targets:

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.