Entry Detail



General Information

Database ID:exR0356342
RNA Name:hsa-miR-129-5p
RNA Type:miRNA
Chromosome:chr7
Starnd:+
Coordinate:
Start Site(bp):128207876End Site(bp):128207896
External Links:hsa-miR-129-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TNRC6B
chr22
40044817
40335808
+
KRIT1
chr7
92198969
92246166
-
SLC7A2
chr8
17497088
17570573
+
TRIM71
chr3
32817997
32897824
+
SHCBP1
chr16
46578591
46621379
-
NEDD4
chr15
55826922
55993746
-
ZNF605
chr12
132918306
132956306
-
DDX18
chr2
117814691
117832377
+
CPSF7
chr11
61402641
61430031
-
RAD1
chr5
34905260
34918989
-
UBN2
chr7
139230356
139308236
+
DEGS1
chr1
224175756
224193441
+
SEC62
chr3
169966635
169998373
+
CRK
chr17
1420689
1463162
-
SLC35E1
chr19
16549831
16572415
-
TRIM14
chr9
98069275
98119222
-
ALDH5A1
chr6
24494867
24537207
+
UFL1
chr6
96521595
96555276
+
DUSP14
chr17
37489891
37513501
+
WSB1
chr17
27294076
27315926
+
DNAJC24
chr11
31369840
31432835
+
CHURC1
chr14
64914361
64944591
+
MLEC
chr12
120687149
120701859
+
CAMTA1
chr1
6785454
7769706
+
THUMPD1
chr16
20702816
20742084
-
EIF4A1
chr17
7572706
7579006
+
ACER3
chr11
76860867
77026797
+
TTPAL
chr20
44475874
44494603
+
PDS5A
chr4
39822863
39977956
-
FBXW7
chr4
152320544
152536092
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0001168
chr20
47691321
47707559
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004069.1
chr4
105137280
105140619
-
AC097634.1
chr3
71584943
71587409
+
AL049795.2
chr1
32170733
32176568
+
FGD5-AS1
chr3
14920347
14948424
-
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NUTM2A-AS1
chr10
87201647
87342612
-
OIP5-AS1
chr15
41283990
41309737
+
TBC1D3P1-DHX40P1
chr17
59962363
60018975
-
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.