Entry Detail



General Information

Database ID:exR0356395
RNA Name:hsa-miR-138-5p
RNA Type:miRNA
Chromosome:chr16
Starnd:+
Coordinate:
Start Site(bp):56858527End Site(bp):56858549
External Links:hsa-miR-138-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
KRT80
chr12
52168996
52192014
-
STX3
chr11
59713456
59805882
+
SIN3A
chr15
75369379
75455842
-
RNH1
chr11
494512
507300
-
ACTN4
chr19
38647649
38731589
+
CDCA7L
chr7
21900899
21945903
-
COPS7B
chr2
231781671
231809254
+
LARP4B
chr10
806914
931705
-
GSK3A
chr19
42230190
42242625
-
GNAI2
chr3
50226292
50259362
+
NINJ1
chr9
93121496
93134251
-
IGF2BP1
chr17
48997385
49056145
+
TFAP2A
chr6
10393186
10419659
-
FOXC1
chr6
1609915
1613897
+
PATL1
chr11
59636716
59669037
-
SRF
chr6
43171269
43181506
+
MAFG
chr17
81918270
81927735
-
AHDC1
chr1
27534035
27604431
-
FOXP4
chr6
41546426
41602384
+
HIF1AN
chr10
100529072
100559998
+
PRKACA
chr19
14091688
14118084
-
SMG1
chr16
18804853
18926454
-
IQGAP1
chr15
90388242
90502239
+
CTDSP1
chr2
218398256
218405941
+
HMGA1
chr6
34236873
34246231
+
KLF11
chr2
10042849
10054836
+
ZHX2
chr8
122781655
122974510
+
IQSEC1
chr3
12897043
13283281
-
PLXNB2
chr22
50274979
50307646
-
TRIB1
chr8
125430358
125438403
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001454
chr4
154524454
154533552
+
hsa_circ_0000402
chr12
53670403
53671011
+
hsa_circ_0000798
chr17
65941524
65944422
+
hsa_circ_0001146
chr20
34241449
34246936
-
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC092718.4
chr16
81030770
81031485
+
AC144548.1
chr12
110387463
110445548
-
AL137127.1
chr1
19072110
19075511
-
H19
chr11
1995176
2001470
-
MCF2L-AS1
chr13
112967484
112968824
-
MCM3AP-AS1
chr21
46229196
46259390
+
NEAT1
chr11
65422774
65445540
+
PARD6G-AS1
chr18
80147924
80179839
+
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
TUG1
chr22
30969245
30979395
+
TFAP2A-AS1
chr6
10409340
10416446
+
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.